SrasV1, Main, Exploration, bibRecord, 003710

Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus▿

Identifieur interne : 003710 ( Main/Exploration ); précédent : 003709; suivant : 003711

Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus▿

Auteurs : Chung-Chau Hon ; Tsan-Yuk Lam ; Zheng-Li Shi ; Alexei J. Drummond ; Chi-Wai Yip ; Fanya Zeng ; Pui-Yi Lam ; Frederick Chi-Ching Leung

Source :

Journal of Virology [ 0022-538X ] ; 2007.

RBID : PMC:2258724

Descripteurs français

KwdFr :
- Animaux, Chiroptera (virologie), Données de séquences moléculaires, Génome viral (génétique), Modèles génétiques, Phylogénie, Recombinaison génétique, Séquence nucléotidique, Théorème de Bayes, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (isolement et purification).
MESH :
- génétique : Génome viral, Virus du SRAS.
- isolement et purification : Virus du SRAS.
- virologie : Chiroptera.
- Animaux, Données de séquences moléculaires, Modèles génétiques, Phylogénie, Recombinaison génétique, Séquence nucléotidique, Théorème de Bayes, Virus du SRAS.

English descriptors

KwdEn :
- Animals, Base Sequence, Bayes Theorem, Chiroptera (virology), Genome, Viral (genetics), Models, Genetic, Molecular Sequence Data, Phylogeny, Recombination, Genetic, SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification).
MESH :
- classification : SARS Virus.
- genetics : Genome, Viral, SARS Virus.
- isolation & purification : SARS Virus.
- virology : Chiroptera.
- Animals, Base Sequence, Bayes Theorem, Models, Genetic, Molecular Sequence Data, Phylogeny, Recombination, Genetic.

Abstract

Bats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258724

DOI: 10.1128/JVI.01926-07
PubMed: 18057240
PubMed Central: 2258724

Affiliations:

Le document en format XML

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<term>Models, Genetic</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
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<front><div type="abstract" xml:lang="en"><p>Bats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV.</p>
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Serveur d'exploration SRAS

Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus▿

Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus▿

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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